The increased prominence of environmental, social, and governance (ESG) factors in investment decision-making comes with increased responsibility to ensure that sustainable investment is demonstrating real-world outcomes. ISS ESG has compiled the global and regional ESG themes and trends that have emerged on our radar as the key issues to focus on this year. Using ISS ESG data, analyst commentary, and comprehensive qualitative research from the ISS ESG global database, this paper acts as a year-long resource for investors seeking to navigate the potentialities of diverse global and regional ESG issues and their impacts across various investment markets.